This Black Lives Matter! Special Issue uses diverse methods to examine how multiple systems of oppression at different levels (individual, institutional, and structural) affect Black youth. Through an intersectionality lens, scholars examine how gender, sexual orientation, skin tone, and socioeconomic status create unique experiences for Black youth. Collectively, the 17 papers address the sweeping impact of racism and other systems of oppression on Black youth by examining structural factors (e.g., policing), interpersonal experiences (e.g., teacher–student), and developmental processes (e.g., socialization). Commentaries provide a historical view and future perspective to contextualize how far we have come and how much farther we need to go in our quest to combat racism and other systems of oppression and improve the lives of Black adolescents.