Differential reinforcement of alternative behavior is a common intervention for problem behavior in persons with neurodevelopmental disorders, but it is susceptible to integrity errors that can degrade treatment effects. Manipulating reinforcement parameters to favor alternative behavior might make it more persistent in the face of integrity errors. We devised an analog of differential reinforcement of alternative behavior to examine if enhanced reinforcer magnitude or quality for the alternative response could protect against treatment degradation. Across 2 experiments, reinforcer magnitude or quality was manipulated to favor the alternative response in 1 condition but kept constant across both alternative and target responses in a second condition. Comparisons of the 2 conditions indicated that higher-magnitude or higher-quality reinforcement for alternative behavior can mitigate against treatment degradation when treatment errors occur and provided support for the utility of considering parameters of reinforcement when developing behavioral interventions for problem behavior.