The arrival of unaccompanied minors from Africa in Spanish territory has been a constant since the last decade of the twentieth century. This migratory phenomenon has forced the child welfare system to attend to thousands of migrant children. The transition to adult life is a decisive stage in overcoming the situation of social exclusion. This research aims to analyse which socio-educational intervention strategies are effective during the process of transition to independent living with unaccompanied minors of African origin. We designed a qualitative research according to the grounded theory, which we divided into two phases. Twenty-nine young people (26 men and 3 women) participated. In phase 1, we performed two focus groups (N = 11), and in phase 2, we conducted longitudinal follow-ups (N = 18) for 24 months through 180 interviews. The results indicate the effectiveness of designing socio-educational accompaniment, prioritizing spaces of trust from which to attain the goals of emancipation. Young people consider effective those strategies that favour their knowledge of the social, labour and legal reality of the host society, designed considering each minor’s individualized situation. We concluded that professional involvement acts as a buffer, reducing the bureaucratic obstacles implemented by the Spanish government.