This study aimed to establish the association of low social capital (SC) with psychological distress indicators. A cross‐sectional study was carried out using an online questionnaire that evaluated demographic variables, social capital, perceived stress related to coronavirus disease, depression risk, insomnia risk, and suicide risk. SC was taken as an independent variable, and symptoms indicating psychological distress were considered as dependent variables. A group of 700 adults aged between 18 and 76 years (M = 37, SD = 13) participated in the survey. Low SC was associated with depression risk (odds ratio [OR] = 2.00, 95% confidence interval [CI] = 1.34–2.97), elevated suicide risk (OR = 2.62, 95% CI = 1.40–4.91) high perceived stress related to coronavirus disease (OR = 2.08 95% CI, 1.15–3.76), and insomnia risk (OR = 2.42, 95% CI = 1.69–3.47). In conclusion, low CS was associated with indicators of psychological distress. SC is a community social resource that could help mitigate the quarantine impact of coronavirus disease amidst the Colombian population’s psychological health.