The COVID-19 pandemic and resulting containment policies have hit the Philippines harder than most developing countries. The government’s lockdown is among the strictest globally, and school closures are the lengthiest on a blanket basis. This paper uses a novel simulation model to estimate the gendered and regional impacts of the pandemic and lockdown on labor, income, and poverty. Our case study of school closures shows additional losses in employment of private school teachers and in income of parents of young children. We find that the pandemic and lockdown have had unprecedent implications for economic activity and have disproportionately affected women.