Depression is a common complication of pregnancy and is estimated to affect 9.2% of pregnant women in high-income countries, according to a 2017 meta-analysis. Prenatal depression is associated with negative outcomes, including elevated risk of postpartum depression and chronic mental illness in women, preterm birth and other perinatal complications, and child developmental, social, and behavioral problems. As such, treatment of depression in pregnancy is a priority for affected women, their children, and their families. Psychotherapies may be effective to treat depression of mild and moderate severity; however, antidepressants may be required to effectively treat more severe depression or when therapy does not lead to remission. Therefore, the short-term and long-term outcomes of fetal exposure to antidepressant medications must be considered.