Publication date: Available online 15 July 2019
Source: Journal of Obsessive-Compulsive and Related Disorders
Author(s): Ana Rabasco, Miriam Ambrosino, Dean McKay
The Research Domain Criteria (RDoC) emphasizes the discovery of mechanisms of psychopathology and treatment outcome. In the case of Obsessive-Related Disorders (OCRDs), the available research shows that research exists that describes negative valence variables, specifically neural circuitry, that may be mediators of cognitive-behavioral treatment (CBT) outcome for obsessive-compulsive disorder (OCD). There is limited research on neural circuitry associated with CBT outcome in the other OCRDs. A small body of work exists on cognitive processes, as defined by the RDoC, in the context of mechanisms of OCD treatment outcome. The other major domains of the RDoC have not been addressed for any OCRD in association with CBT outcome. The review concludes with a broad research agenda that emphasizes: clarification of taxonomic features of obsessive-compulsive psychopathology; explicate this taxonomy of obsessive-compulsive psychopathology in relation to neural circuitry; and identify limits of these findings based on culture and environment. It is expected that this research agenda would lead to a clinical heuristic to aid cognitive behavior therapy providers in developing targeted interventions for the full range of OCRDs.