There are numerous examples in the homicide literature of a presumed connection between the victim–offender relationship and the manner, extent, and body location of wounds inflicted in homicides. The current study examined variations in wounding patterns according to the intimacy of the victim–offender relationship in a sample of urban homicides to explore the investigative utility of this information in an average homicide event. The findings demonstrated that victims who had a current or former intimate relationship with their offender were more likely to receive wounds to the face and be injured with a weapon from the scene compared with all other relationship groups, whereas injury to the head and use of manual violence were more likely among intimates and family/friends compared with acquaintances or strangers. However, the groups did not significantly differ in terms of the overall amount of wounds inflicted. Implications of the findings and suggested areas of future research are discussed.