Shifts in the ways that science is being undertaken and marshaled toward social change argue for a new kind of professional competence. Taking the view that the science of social work is centrally about the relationship of research to social impact, the authors extend Fong’s focus on transdisciplinary and translational approaches to science, illustrating ways that national and international priorities are exerting enormous influence in structures for and expectations of science relevant to social work. The authors also emphasize the growing centrality of transformational research, focusing in particular on the interdependence of education and impact. The intent is to stimulate reflectiveness regarding social work’s preparedness to support and indeed amplify a robust culture of high impact science, including more confident, clearly articulated roles and skills in this contemporary scientific landscape.