This study investigated the associations among relational uncertainty, communication efficacy, and the frequency and comfort of discussing religious topics in romantic relationships. Participants included 204 young adults currently involved in a romantic relationship. Results indicated that relational uncertainty was inversely associated with the frequency and comfort with which dating partners discuss religious (and/or spiritual) topics. Communication efficacy, however, was positively associated with both outcomes. Moreover, effects for uncertainty and efficacy were moderated by levels of intimacy and perceived similarity in religious affiliation. Consequently, the results provide meaningful extensions to emerging theories of relational uncertainty and information management in romantic relationships.