This study helps to disentangle the mutual effects of neighborhood disorder and social cohesion on how residents evaluate their neighborhoods. We draw upon data from the 2009 Las Vegas Metropolitan Area Social Survey to understand how neighborhood cohesion, physical disorder, and perceptions of crime and safety influence neighborhood satisfaction and neighborhood quality of life among residents in the dynamic, yet understudied, urban context of Las Vegas, Nevada. We use ordinary least squares and binary logistic regression to predict two measures of neighborhood satisfaction. Our results show that even with significant neighborhood disorder, social connectedness with neighbors remains a significant predictor of neighborhood satisfaction. We discuss implications of neighborhood satisfaction research for other fast-changing metropolitan areas.