Abstract
Identifying risk factors for Alzheimer’s disease, such as carrying the APOE-4 allele, and understanding their contributions
to disease pathophysiology or clinical presentation is critical for establishing and improving diagnostic and therapeutic
strategies. A first-degree family history of Alzheimer’s disease represents a composite risk factor, which reflects the influence
of known and unknown susceptibility genes and perhaps non-genetic risks. There is emerging evidence that investigating family
history risk associated effects may contribute to advances in Alzheimer’s disease research and ultimately clinical practice.
to disease pathophysiology or clinical presentation is critical for establishing and improving diagnostic and therapeutic
strategies. A first-degree family history of Alzheimer’s disease represents a composite risk factor, which reflects the influence
of known and unknown susceptibility genes and perhaps non-genetic risks. There is emerging evidence that investigating family
history risk associated effects may contribute to advances in Alzheimer’s disease research and ultimately clinical practice.
- Content Type Journal Article
- Category Review
- Pages 1-12
- DOI 10.1007/s11065-012-9193-2
- Authors
- Markus Donix, Department of Psychiatry and Psychotherapy, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany
- Gary W. Small, David Geffen School of Medicine at UCLA, Department of Psychiatry and Biobehavioral Sciences, Semel Institute, Los Angeles, CA 90095, USA
- Susan Y. Bookheimer, David Geffen School of Medicine at UCLA, Center for Cognitive Neurosciences, Semel Institute, Los Angeles, CA 90095, USA
- Journal Neuropsychology Review
- Online ISSN 1573-6660
- Print ISSN 1040-7308