Despite burgeoning research on coping with stress and its crucial role on people’s psychological and physical well-being, there is a dearth of psychometrically established instrument for use in Iran to measure coping. A Farsi translation of the Ways of Coping questionnaire (WOC) was administered to 739 participants from Tehran, Iran. The factor structure of the WOC was assessed with both explanatory and confirmatory factor analyses. A 7-factor structure model with some important similarities and differences to the original version from the United States was confirmed. The Farsi version of WOC was found to have good construct reliability and model fit and has considerable potential to be used in future coping research among Iranian populations.