The observed Taiwanese neonatal professionals’ more conservative attitudes than their worldwide colleagues towards end-of-life (EOL) decision making may stem from cultural attitudes toward death in children and concerns about medicolegal liability. Healthcare practice is rooted in local culture and laws; however that should be adjusted to patients’ best interests. Improving Taiwanese neonatal professionals’ knowledge and competence in EOL care may minimize ethical dilemmas, allow appropriate EOL care decision making, avoid infants’ suffering, and ease parents’ bereavement grief.