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Does Nausea and Vomiting of Pregnancy Play a Role in the Association Found Between Maternal Caffeine Intake and Fetal Growth Restriction?

Abstract  

The aim of this study was to explore the relationships between nausea and vomiting in pregnancy and (a) fetal growth restriction;
and (b) maternal caffeine metabolism and fetal growth restriction. A cohort of 2,643 pregnant women, aged 18–45 years, attending
two UK maternity units between 8 and 12 weeks gestation, was recruited. A validated tool assessed caffeine intake at different
stages of pregnancy and caffeine metabolism was assessed from a caffeine challenge test. Experience of nausea and vomiting
of pregnancy was self-reported for each trimester. Adjustment was made for confounders, including salivary cotinine as a biomarker
of current smoking status. There were no significant associations between fetal growth restriction and nausea and vomiting
in pregnancy, even after adjustment for smoking and alcohol intake. There were no significant differences in the relationship
between caffeine intake and fetal growth restriction between those experiencing symptoms of nausea and vomiting and those
who did not, for either the first (p = 0.50) or second trimester (p = 0.61) after adjustment for smoking, alcohol intake and caffeine half-life. There were also no significant differences in
the relationship between caffeine half-life and fetal growth restriction between those experiencing symptoms of nausea and
vomiting and those who did not, for either the first trimester (p = 0.91) or the second trimester (p = 0.45) after adjusting for smoking, alcohol intake and caffeine intake. The results from this study show no evidence that
the relationship between maternal caffeine intake and fetal growth restriction is modified by nausea and vomiting in pregnancy.

  • Content Type Journal Article
  • Pages 1-8
  • DOI 10.1007/s10995-012-1034-7
  • Authors
    • S. M. Boylan, Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT UK
    • D. C. Greenwood, Biostatistics Unit, Centre for Epidemiology and Biostatistics, University of Leeds, Worsley Building, Leeds, LS2 9JT UK
    • N. Alwan, Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT UK
    • M. S. Cooke, University of Leicester, Leicester, LE2 7LX UK
    • V. A. Dolby, Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT UK
    • A. W. M. Hay, Molecular Epidemiology Group, University of Leeds, Leeds, UK
    • S. F. L. Kirk, Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT UK
    • J. C. Konje, University of Leicester, Leicester, LE2 7LX UK
    • N. Potdar, University of Leicester, Leicester, LE2 7LX UK
    • S. Shires, Molecular Epidemiology Group, University of Leeds, Leeds, UK
    • N. A. B. Simpson, Division of Obstetrics and Gynaecology, Leeds General Infirmary, Leeds, LS2 9NS UK
    • N. Taub, University of Leicester, Leicester, LE2 7LX UK
    • J. D. Thomas, Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT UK
    • J. J. Walker, Department of Obstetrics and Gynaecology, St. James University Hospital, Leeds, LS9 7TL UK
    • K. L. M. White, Molecular Epidemiology Group, University of Leeds, Leeds, UK
    • C. P. Wild, Molecular Epidemiology Group, University of Leeds, Leeds, UK
    • J. E. Cade, Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT UK
    • Journal Maternal and Child Health Journal
    • Online ISSN 1573-6628
    • Print ISSN 1092-7875
Posted in: Journal Article Abstracts on 06/03/2012 | Link to this post on IFP |
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