This study describes the development and psychometric properties of the Dutch brief form of the Multidimensional Personality Questionnaire (MPQ-BF-NL). Representative samples from the Netherlands (N = 1,055) and the United States (N = 1,153) and a Dutch student sample (N = 987) were used for development, cross- and external validation, respectively. The authors’ strategy for item selection and scale validation replicated the development of the U.S. brief form (MPQ-BF). Internal consistencies were generally good and comparable to the U.S. version, as were correlations with the U.S. full-length scales and higher order structure. Moreover, convergent and divergent patterns were consistent with prediction, with Positive Emotionality related to social and activating behavior, Negative Emotionality to anxiety, and Constraint to reversed impulsivity and externalizing behaviors. In sum, the MPQ-BF-NL provides the Dutch-Flemish language area with a personality inventory well suited for both psychopathology research and clinical practice and offers new opportunities for fundamental and cross-cultural studies on personality.