The authors describe a model that incorporates cultural competence principles from clinical practice into a mixed methods framework, thus providing a new perspective that reconciles some of the historically perceived differences in paradigmatic stances. The authors present direct connections from each principle to the application of a mixed methods study. An example of a study of a welfare policy is presented along with a critique concerning the appropriate application of principles of clinical cultural competence. The authors conclude that in applying these principles to mixed methods cultural awareness efforts need to be fostered and encouraged comprehensively in research as well as education.