The goal of this study was to use census information to measure the level of occupational segregation of workers of African descent with respect to whites in various Latin American countries. I further investigated the extent to which segregation levels can be accounted for by different workers’ characteristics. The results show that Afro-Latinos are generally highly segregated across occupations but with high heterogeneity across countries. A large proportion of this segregation would not exist if Afro-Latinos had attained the same education as whites in Brazil and Ecuador, where most segregation occurs across major occupational categories. However, the proportion of occupational segregation explained by educational inequalities is much lower in other countries, where most segregation occurs within the major occupational groups. Further, occupational segregation would be even higher, especially in Costa Rica, if the geographical distribution of black and white populations were similar across these countries.