Can Paranoid Thoughts be Reduced by Targeting Negative Emotions and Self-Esteem? An Experimental Investigation of a Brief Compassion-Focused Intervention

Negative emotional states and low self-esteem play a crucial role in the development of persecutory delusions. This study
therefore tests whether a brief intervention that targets negative emotions and self-esteem will reduce paranoid thoughts
and whether this reduction will be mediated by a decrease in negative emotions and an increase in self-esteem. Healthy participants
(n = 71) with varying levels of subclinical symptoms of psychosis (assessed with the Community Assessment of Psychic Experiences)
were randomly assigned to a compassion-focused (CF) or a neutral control condition. Negative emotions were induced before
the intervention by in sensu exposure to personally relevant distressing situations. Participants were then instructed to
apply a previously trained compassion-focused versus a neutral image. Before and after the intervention paranoid thoughts
were assessed by a state-adapted item from the Paranoia Checklist. Participants in the CF condition reported significantly
lower levels of negative emotion, higher self-esteem and less paranoid thoughts compared to participants in the control condition.
The effect of the CF-intervention on paranoid thoughts was mediated by reduced negative emotions but not by increased self-esteem.
Persons with higher baseline scores on the CAPE responded to the intervention with a significantly stronger reduction of paranoid
thoughts than persons with low or medium baseline scores. Interventions targeting the emotional processes involved in delusion
formation might have potential to prevent the formation of paranoid beliefs in persons at risk of developing psychosis and
reduce delusions in persons with clinically relevant symptom levels.