Persons with disabilities have been underrepresented in the science, technology, engineering, and mathematics (STEM) fields for many years. Reasons for this include low expectations for students with disabilities, limited exposure to prerequisite courses, lack of role models, and lack of access to individualized supports. This article identifies the issues related to the participation of students with learning disabilities and emotional and behavioral disorders in STEM college programs and provides transition planning strategies for assisting and encouraging students as they prepare for and succeed in STEM programs. A case study of a student with a disability who had a goal of pursuing a STEM career illustrates the issues commonly faced by students with disabilities. Research-based planning strategies addressing these issues that help ensure student success are provided.