This Manual is a joint production by the EMCDDA and the Prevention Standards Partnership, and presents and describes basic and expert level quality standards for drug prevention. The standards cover all aspects of drug prevention work, including needs and resource assessment, programme planning, intervention design, resource management, implementation, monitoring and evaluation, dissemination, sustainability, stakeholder involvement, staff development, and ethics. Considerations regarding the standards’ real-life implementation are provided, acknowledging differences in professional culture, policy, and the structure of prevention delivery within Europe.