Youths (N = 57; mean age = 13.83 years) residing near Tororo, Uganda, were interviewed to obtain quantitative and qualitative data pertaining to negative life events, adjustment problems, coping, social support, self-worth, and hope. On average, they experienced nearly half of the 22 negative life events assessed. The experience of negative life events related positively to internalizing problems and negatively to social support and self-worth. Coping strategies (problem-focused, positive reframing, avoidance, and support-seeking) were positively associated with hope. Problem-focused coping was negatively related to externalizing problems. Furthermore, social support was positively associated with coping strategies, self-worth, and hope and was negatively related to adjustment problems. The qualitative data shed light on the difficult events the youths endured and what types of coping strategies they used. Ultimately, interviews suggested that youths experienced many negative events, but they remained optimistic.