Abstract
This study aims at developing a single numerical measure that represents a depressed patient’s individual burden of illness.
An exploratory study examined depressed outpatients (n = 317) followed by a hypothesis confirmatory study using the NIMH STAR*D trial (n = 2,967). Eigenvalues/eigenvectors were obtained from the Principal Component Analyses of patient-reported measures of symptom
severity, functioning, and quality of life. The study shows that a single principal component labeled as the Individual Burden
of Illness Index for Depression (IBI-D) accounts for the vast majority of the variance contained in these three measures providing
a numerical z score for clinicians and investigators to determine an individual’s burden of illness, relative to other depressed patients.
An exploratory study examined depressed outpatients (n = 317) followed by a hypothesis confirmatory study using the NIMH STAR*D trial (n = 2,967). Eigenvalues/eigenvectors were obtained from the Principal Component Analyses of patient-reported measures of symptom
severity, functioning, and quality of life. The study shows that a single principal component labeled as the Individual Burden
of Illness Index for Depression (IBI-D) accounts for the vast majority of the variance contained in these three measures providing
a numerical z score for clinicians and investigators to determine an individual’s burden of illness, relative to other depressed patients.
- Content Type Journal Article
- Category Original Paper
- Pages 1-11
- DOI 10.1007/s10488-011-0376-6
- Authors
- Waguih William IsHak, Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center and David Geffen School of Medicine at UCLA, 8730 Alden Drive, Thalians W-157, Los Angeles, CA 90048, USA
- Jared Matt Greenberg, David Geffen School of Medicine at UCLA and Keck School of Medicine at University of Southern California (USC), Los Angeles, CA, USA
- Tammy Saah, Emory University, Atlanta, GA, USA
- Shakiba Mobaraki, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
- Hala Fakhry, Department of Psychiatry, Faculty of Medicine, Cairo University, Cairo, Egypt
- Qian (Vicky) Wu, Biostatisitics, UCLA School of Public Health, Los Angeles, CA, USA
- Eunis Ngor, Biostatisitics, UCLA School of Public Health, Los Angeles, CA, USA
- Fei Yu, Biostatisitics, UCLA School of Public Health, Los Angeles, CA, USA
- Robert M. Cohen, Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, USA
- Journal Administration and Policy in Mental Health and Mental Health Services Research
- Online ISSN 1573-3289
- Print ISSN 0894-587X