The evolving eHealth agenda presents a range of potential opportunities for the management and prevention of chronic disease. This paper identifies issues and barriers to the uptake of eHealth and describes a strategy (Healthy Outcomes for Australians© – HOFA) for creating a central knowledge filter and cyber space method for tracking health determinants through an interactive, social media platform. Discussion will be directed towards presenting contemporary interactive cyber platforms that are aimed at harnessing social media (Web 2.0) technologies in preparation for delivering effective early 21st century health care.