Survey results from 96 Asian Indians in the USA found that those having depressive symptoms were more likely to have experienced social, family or relationship issues. Logistic regression analysis indicated three significant predictors: 1) individuals with anxiety problems were 11.34 times more likely to have depressive symptoms; 2) each unit increase in the score for family or relationship issues increased the likelihood of depression by 3.74 times; and 3) individuals currently employed were 90.9 percent less likely to have depressive symptoms. Reframing mental health symptoms as reactions to family/social issues will help Asian Indians step forward to seek professional help.