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Applying the PRECIS Criteria to Describe Three Effectiveness Trials of Weight Loss in Obese Patients with Comorbid Conditions

Objectives

To characterize Practice-Based Opportunities for Weight Reduction (POWER) trials along the pragmatic-explanatory continuum.

Settings

The POWER trials consist of three individual studies that target obesity treatment in primary care settings.

Design

Using the PRagmatic Explanatory Continuum Indicator Summary (PRECIS) criteria, nine reviewers independently scored each trial.

Methods

Average and median ratings, inter-rater reliability, and relationships to additional ratings of the extent to which study designs were explanatory (i.e., efficacy) versus pragmatic (i.e., practical) and related to external validity were determined.

Principal Findings

One trial was consistently rated as being significantly more pragmatic than the others (R2 = 0.43, p < .001), although all three were in the moderate range on the PRECIS scales. Ratings varied across PRECIS dimensions, being most pragmatic on comparison condition and primary outcome. Raters, although undergoing training and using identical definitions, scored their own study as more pragmatic than the other studies/interventions.

Conclusions

These results highlight the need for more comprehensive reporting on PRECIS and related criteria for research translation. The PRECIS criteria provide a richer understanding of the POWER studies. It is not clear whether the original criteria are sufficient to provide a comprehensive profile.

Posted in: Journal Article Abstracts on 11/05/2011 | Link to this post on IFP |
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