This article presents an innovative sequential mixed methods approach to researching the experiences of U.K. adults with chronic health conditions seeking health information online. The use of multiple methods integrated within a single study ensured that the focus of the research was emergent and relevant and ultimately provided a more complete picture of the experience of online health information seeking through joint discussion. This was achieved by communicating both breadth and depth of data relating to the phenomenon. Findings indicate that if the study had used a single research method in isolation, something would have been lost or misunderstood regarding the phenomenon, thus demonstrating the value of each stage within the research design and of the integration of these findings.