Adherence to antiretroviral therapy (ART) among people living with HIV infection is critical for treatment success and HIV prevention. As we continue our efforts to optimize health outcomes for individuals living with HIV, the Centers for Disease Control and Prevention (CDC)—with support from adherence experts as well as scientists at the Health Resources and Services Administration, the National Institute of Mental Health, and the National Institute on Drug Abuse —is pleased to announce that we have identified eight evidence-based interventions focusing on medication adherence that improve medication adherence behaviors and viral suppression.