Guided by a developmental epidemiology framework, this study examines the extent to which first experiences of child maltreatment and use of emergency housing are predictive of out-of-home placement in early childhood. The study sample is a population of 12,045 second grade students in a large, urban school district. Information on birth, maternal, and social risk factors was obtained and linked through an integrated data system. Life table analyses were used to develop a descriptive picture of the timing of first out-of-home placement experience. Findings demonstrate that children are most likely to experience a first out-of-home placement during their first year of life.